CONDITIONS WE TREAT
Chronic low-grade inflammation is the silent driver behind a growing spectrum of modern chronic illness — from metabolic disease and autoimmunity to neurodegeneration and accelerated aging. SynergyO3 investigates the upstream biological sources of your inflammatory burden and designs a physician-supervised protocol to address root mechanisms.
CLINICAL PRESENTATION
Chronic inflammation produces symptoms across virtually every body system. Because it underlies so many conditions simultaneously, it is frequently missed as a unifying root cause. Individual results vary — Dr. Volpp evaluates each patient's complete clinical picture.
Acute inflammation is a healthy, protective response. Chronic inflammation arises when the resolution pathways fail — often due to ongoing triggers including gut dysbiosis, environmental toxins, chronic infections, metabolic stress, or persistent psychological stress activating the HPA axis.
Key inflammatory markers may include elevated high-sensitivity CRP, IL-6, TNF-α, fibrinogen, homocysteine, ferritin, and ESR. Metabolic markers including insulin resistance, elevated triglycerides, and oxidized LDL are also commonly elevated in states of chronic systemic inflammation.
COMMONLY OVERLAPPING CONDITIONS
CLINICAL EDUCATION
Chronic inflammation is maintained by a self-perpetuating cycle: inflammatory triggers activate the NF-κB signaling pathway, releasing pro-inflammatory cytokines that generate reactive oxygen species, which in turn activate more NF-κB. Breaking this cycle requires addressing the upstream triggers and restoring oxidative balance.
Nuclear factor kappa B (NF-κB) is a master transcription factor that controls the expression of hundreds of inflammatory genes. Chronic activation by toxins, stress hormones, dysbiosis, and oxidative stimuli creates a sustained inflammatory gene expression program driving systemic disease.
Dysfunctional mitochondria produce excess reactive oxygen species (ROS) that activate inflammatory signaling pathways, damage cellular proteins and DNA, and perpetuate the inflammatory cycle. Restoring mitochondrial health is a key target in chronic inflammation management.
Imbalanced gut microbiota produces lipopolysaccharide (LPS) and other bacterial products that cross a compromised intestinal barrier and continuously activate toll-like receptors (TLRs) on immune cells, maintaining systemic low-grade inflammation.
KEY STATISTICS
Comprehensive intake, targeted labs, and biomarker assessment to map biological drivers.
Physician-designed sequenced protocol combining EBOO, HOCATT, and IV nutrients.
Follow-up labs, functional benchmarks, and protocol refinement based on response.
ROOT CAUSE INVESTIGATION
Dr. Volpp evaluates each patient's complete picture — identifying which biological mechanisms are most active — before any protocol is designed. Individual results vary.
Chronic inflammatory states deplete endogenous antioxidants including glutathione, superoxide dismutase, and catalase — allowing ROS accumulation that damages cellular lipids, proteins, and DNA while amplifying the inflammatory signal.
Elevated pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) relative to anti-inflammatory mediators (IL-10, TGF-β) sustain inflammatory tissue damage and systemic symptoms. This imbalance drives everything from joint inflammation to neuroinflammation.
Chronic stress activates the hypothalamic-pituitary-adrenal axis, initially elevating cortisol (anti-inflammatory) but eventually leading to cortisol resistance and paradoxical pro-inflammatory signaling that perpetuates chronic inflammation.
TREATMENT APPROACH
All protocols are physician-designed and supervised by Dr. Heather Volpp, MD. Therapies are selected based on each patient's evaluation. Results may vary.
EBOO ozone therapy activates the Nrf2 transcription factor — the master regulator of cellular antioxidant response — potentially reducing the oxidative burden that sustains chronic inflammation and supporting resolution rather than ongoing activation.
The HOCATT's multi-modal approach including ozone steam, far-infrared, and carbonic acid may reduce systemic inflammatory burden, support lymphatic clearance of inflammatory mediators, and modulate autonomic nervous system tone.
YOUR PATH FORWARD
Every patient begins with a comprehensive physician evaluation. No protocol begins before Dr. Volpp has reviewed your complete clinical picture.
A comprehensive intake with Dr. Volpp reviewing your symptom timeline, prior lab work, medications, and functional status. Targeted lab panels are ordered to identify active biological drivers.
Based on your evaluation findings, Dr. Volpp designs a sequenced treatment protocol — typically combining EBOO sessions, HOCATT therapy, and IV nutrient support at clinically appropriate intervals.
Functional benchmarks and symptom tracking guide protocol adjustments. Follow-up labs assess inflammatory markers and key biomarkers. Treatment frequency is adjusted as you progress toward your goals.
COMMON QUESTIONS
TAKE THE NEXT STEP
Begin with a comprehensive consultation with Dr. Heather Volpp, MD — Board-Certified Internal Medicine. Your evaluation will review your full clinical picture and identify which biological mechanisms may be driving your symptoms.
Book Your Appointment →Physician-Supervised · SynergyO3 Medical · Encinitas, CA · (760) 450-4602
Individual results vary. Consult with Dr. Volpp during your evaluation.
