CONDITIONS WE TREAT
Longevity medicine focuses on extending healthspan — the years of healthy, functional life — not just lifespan. SynergyO3 targets the upstream biological drivers of accelerated aging: mitochondrial decline, oxidative damage, cellular senescence, and chronic inflammation — to help you function at your peak for longer.
CLINICAL PRESENTATION
Biological aging accelerates when cellular repair and regeneration can no longer keep pace with damage accumulation. Many people experience accelerated biological aging years before it becomes clinically apparent. Dr. Volpp evaluates your biological age markers to identify areas most responsive to intervention.
SynergyO3 evaluates biological age indicators including telomere length, mitochondrial function markers, oxidative stress biomarkers (8-OHdG, isoprostanes), advanced glycation end-products, inflammatory age markers (inflammaging), NAD+ levels, and functional capacity assessments.
Key longevity biomarkers include NAD+ levels, oxidative stress markers (8-OHdG, isoprostanes), advanced glycation end-products (AGEs), inflammatory indices (CRP, IL-6), telomere length assessment, mitochondrial respiratory function, HRV, and VO₂ max.
COMMONLY OVERLAPPING CONDITIONS
CLINICAL EDUCATION
Biological aging is driven by the gradual accumulation of cellular damage that exceeds repair capacity. The hallmarks of aging include mitochondrial dysfunction, oxidative DNA damage, cellular senescence, telomere attrition, epigenetic dysregulation, and chronic low-grade inflammation ('inflammaging'). These mechanisms are interconnected and mutually reinforcing.
Mitochondrial function declines with age due to accumulating oxidative damage to mitochondrial DNA and electron transport chain components. NAD+ — critical for mitochondrial energy production and sirtuin activation — falls dramatically with age, accelerating virtually every hallmark of aging.
Senescent cells have stopped dividing but remain metabolically active, secreting a pro-inflammatory cocktail called the Senescence-Associated Secretory Phenotype (SASP). Accumulating senescent cells drive tissue dysfunction, chronic inflammation, and accelerated aging in neighboring cells.
Reactive oxygen species accumulating with age damage nuclear and mitochondrial DNA, causing telomere shortening with each cell division. Short telomeres trigger cell senescence or apoptosis, reducing tissue regenerative capacity and driving organ function decline.
KEY STATISTICS
Comprehensive intake, targeted labs, and biomarker assessment to map biological drivers.
Physician-designed sequenced protocol combining EBOO, HOCATT, and IV nutrients.
Follow-up labs, functional benchmarks, and protocol refinement based on response.
ROOT CAUSE INVESTIGATION
Dr. Volpp evaluates each patient's complete picture — identifying which biological mechanisms are most active — before any protocol is designed. Individual results vary.
NAD+ is required for sirtuin enzymes (SIRT1-7) that regulate DNA repair, mitochondrial biogenesis, inflammation, and metabolic efficiency. Declining NAD+ with age disables these longevity pathways — accelerating mitochondrial dysfunction and cellular aging.
Chronic low-grade inflammation ('inflammaging') accumulates with age from senescent cells, microbiome changes, oxidative burden, and accumulated damage signals. Elevated IL-6, TNF-α, and CRP are independent predictors of biological aging rate and mortality.
With aging, the signaling pathways that trigger mitochondrial biogenesis (PGC-1α, AMPK) become less responsive. Fewer new mitochondria are produced while damaged ones accumulate, reducing cellular energy capacity and stress resilience.
TREATMENT APPROACH
All protocols are physician-designed and supervised by Dr. Heather Volpp, MD. Therapies are selected based on each patient's evaluation. Results may vary.
EBOO ozone therapy may activate key longevity signaling pathways including Nrf2 (antioxidant response), support mitochondrial biogenesis, reduce the oxidative burden that accelerates cellular aging, and improve tissue oxygen delivery.
The HOCATT's combination of ozone, far-infrared, and carbonic acid activates multiple longevity pathways — stimulating heat shock proteins, improving circulation, reducing systemic oxidative burden, and supporting autonomic balance.
YOUR PATH FORWARD
Every patient begins with a comprehensive physician evaluation. No protocol begins before Dr. Volpp has reviewed your complete clinical picture.
A comprehensive intake with Dr. Volpp reviewing your symptom timeline, prior lab work, medications, and functional status. Targeted lab panels are ordered to identify active biological drivers.
Based on your evaluation findings, Dr. Volpp designs a sequenced treatment protocol — typically combining EBOO sessions, HOCATT therapy, and IV nutrient support at clinically appropriate intervals.
Functional benchmarks and symptom tracking guide protocol adjustments. Follow-up labs assess inflammatory markers and key biomarkers. Treatment frequency is adjusted as you progress toward your goals.
COMMON QUESTIONS
TAKE THE NEXT STEP
Begin with a comprehensive consultation with Dr. Heather Volpp, MD — Board-Certified Internal Medicine. Your evaluation will review your full clinical picture and identify which biological mechanisms may be driving your symptoms.
Book Your Appointment →Physician-Supervised · SynergyO3 Medical · Encinitas, CA · (760) 450-4602
Individual results vary. Consult with Dr. Volpp during your evaluation.
