Chronic Illness

Chronic Fatigue &
Long COVID

Long COVID and post-viral chronic fatigue represent one of the largest and most underserved patient populations we see. Persistent fatigue, brain fog, breathlessness, and immune dysregulation — often months or years after initial infection — point to something happening at the cellular level that standard recovery protocols simply don't address.

"The mechanism is real. Micro-clotting, mitochondrial impairment, and a locked inflammatory state are measurable. EBOO addresses all three simultaneously — which is why so many long COVID patients notice change within their first few sessions." — Dr. Heather Volpp, MD

The Mechanism

Why EBOO Works for Post-Viral Fatigue

Long COVID creates persistent micro-clots in the bloodstream that impair oxygen delivery to tissues. EBOO's extracorporeal process ozonates and hyperoxygenates the blood, breaking down these fibrin microclots and restoring cellular oxygen availability — directly addressing one of the primary drivers of long COVID fatigue.

Mitochondrial Support

Restoring the Cellular Energy Crisis

Post-viral illness disrupts mitochondrial respiration — the process by which cells produce ATP energy. Ozone therapy has been shown to stimulate mitochondrial activity and upregulate antioxidant pathways. Patients frequently report improved energy as one of the earliest and most consistent changes noticed after EBOO treatment.

Patient Pattern

"My labs are normal but I can't function."

This is the most common thing long COVID patients say when they call us. Standard labs don't capture microclot burden, mitochondrial impairment, or cytokine dysregulation. A physician-reviewed intake starts the process of understanding what's actually happening in your system.

Environmental Illness

Mold &
Environmental Toxins

Mycotoxin burden, heavy metal accumulation, and chemical exposure create a toxic load that is fat-soluble, lipophilic, and capable of crossing the blood-brain barrier. Mold illness — clinically known as CIRS — is one of the most underdiagnosed conditions in modern medicine, frequently dismissed because standard bloodwork is not designed to detect it.

"If you've seen multiple specialists, had 'normal' labs, and still feel unwell — mold and environmental toxic burden should be seriously considered. It's not in your head. It's in your cells." — Dr. Heather Volpp, MD

Why HOCATT® Matters Here

Reaching Fat-Stored Toxins

Mycotoxins are lipophilic — they store in fat tissue. IV ozone reaches the blood; HOCATT®'s transdermal ozone penetrates subcutaneous layers during hyperthermia, reaching where fat-soluble toxins accumulate. For mold patients, HOCATT® isn't optional — it's a critical part of the protocol.

MCAS Consideration

Mast Cell Activation & EBOO

MCAS is common in mold patients and requires additional clinical consideration before EBOO. This is why the physician consultation is a required first step — Dr. Volpp reviews your full picture before any protocol begins. MCAS does not automatically preclude EBOO, but the protocol may need to be adjusted.

Herxheimer Reaction

What to Expect in the First 48 Hours

Some mold patients experience a temporary increase in symptoms after their first session — fatigue, headache, brain fog — as toxins are mobilized rapidly. This is a recognized detox response, not a reason to stop treatment. Dr. Volpp discusses pacing during your consultation.

Chronic Illness

Lyme Disease &
Co-Infections

Chronic Lyme disease — including Bartonella, Babesia, Ehrlichia, and other tick-borne co-infections — creates a persistent pathogen burden that challenges even the most aggressive antibiotic protocols. Ozone therapy creates an oxidative environment that is inherently hostile to anaerobic organisms like Borrelia burgdorferi, offering a powerful adjunctive tool alongside conventional treatment.

"Lyme patients often come to us after years of antibiotic treatment that helped but didn't resolve the picture. Ozone works on a fundamentally different mechanism — it changes the environment, not just targets the pathogen." — Dr. Heather Volpp, MD

The Science

Why Borrelia Doesn't Like Ozone

Borrelia burgdorferi is an anaerobic organism — it thrives in low-oxygen, low-oxidative environments. Ozone creates the opposite: a highly oxygenated, oxidatively active environment that disrupts the organism's metabolic function and membrane integrity. UV light in EBO2 adds a direct antimicrobial mechanism.

Herx Awareness

Managing the Herxheimer Response

Lyme patients are often familiar with Herxheimer reactions from antibiotic treatment. EBOO can produce a similar response as pathogen die-off occurs. Dr. Volpp discusses this during your consultation and designs the pacing of your protocol accordingly — starting more conservatively and building from your response.

Co-Infections

Bartonella, Babesia & Beyond

Many Lyme patients carry co-infections that complicate the clinical picture and resist single-pathogen treatment strategies. EBOO's systemic oxidative effect works across pathogen types simultaneously — which is one reason it's particularly valuable in complex tick-borne illness presentations.

Immune Dysregulation

Autoimmune
Conditions

Autoimmune disease represents the immune system in a state of chronic miscommunication — attacking the body's own tissues in a pattern that conventional immunosuppressive medications manage but rarely resolve at the root. EBOO ozone therapy works through immune modulation, not suppression — helping recalibrate the cytokine environment that drives autoimmune flares.

"There's an important distinction between suppressing immune activity and recalibrating it. EBOO doesn't mute the immune system — it helps reset the signaling environment that's causing it to misfire." — Dr. Heather Volpp, MD

Cytokine Modulation

Resetting the Inflammatory Signal

Autoimmune flares are driven by dysregulated cytokine production — specifically pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β. Ozone therapy has been studied for its ability to modulate these pathways, shifting the cytokine environment toward a more balanced state without broadly suppressing immune function.

Current Medication Disclosure

Immunosuppressants & EBOO

If you are currently on immunosuppressive medications — biologics, corticosteroids, DMARDs — full disclosure is required during your physician consultation. Dr. Volpp reviews all medications before designing any protocol. EBOO is not always contraindicated with these agents, but the interaction must be evaluated clinically.

Realistic Expectations

What EBOO Can & Can't Do

EBOO is an adjunctive tool in autoimmune management — not a replacement for disease-modifying therapy in serious conditions. Dr. Volpp will be direct during your consultation about where ozone therapy fits in your overall picture and what outcomes are realistic for your specific diagnosis and history.

Adjunctive Support

Cancer
Support

SynergyO3 does not treat cancer. What we offer is adjunctive support for patients who are in active treatment, in remission, or managing a chronic cancer diagnosis — and who want to support every system in their body that can contribute to their resilience, recovery, and quality of life. EBOO helps address the systemic inflammatory burden, immune dysregulation, and oxidative stress that accompany cancer and its treatments.

"When a patient is fighting, I want to support every system that can help. EBOO doesn't treat cancer — but it can support the body's capacity to respond to the treatment that does." — Dr. Heather Volpp, MD

Important Disclaimer

EBOO Is Not a Cancer Treatment

We state this clearly: EBOO ozone therapy is not approved by the FDA as a cancer treatment and should not replace oncological care. Patients receiving active chemotherapy or radiation must disclose this fully during consultation, as timing relative to treatment sessions is clinically relevant and must be managed carefully.

Where EBOO May Help

Systemic Support During Treatment

Cancer and its treatments create significant oxidative stress, immune dysregulation, and inflammatory burden. EBOO's systemic oxygenation and immune-modulating effects may support energy levels, immune resilience, and reduction in treatment-related fatigue — contributing to a better quality of life alongside conventional care.

Oncologist Coordination

We Work Alongside Your Care Team

For patients in active treatment, we strongly recommend informing your oncologist that you are pursuing adjunctive ozone therapy. Dr. Volpp is available to communicate with your care team if needed. Integrated care — not competing care — is always the goal.

Heart & Vascular Health

Cardiovascular
Support

Cardiovascular inflammation — not cholesterol alone — is increasingly recognized as the primary driver of arterial disease, heart attacks, and stroke risk. Standard lipid panels capture only a fraction of the picture. EBOO ozone therapy improves blood oxygen delivery, reduces inflammatory burden in circulation, and pairs powerfully with precision cardiovascular testing that goes beyond what routine labs reveal.

"Your cholesterol panel may look fine. But inflammatory markers in your arterial wall tell a different story. We have a test that measures both — and a protocol designed to address what it finds." — Dr. Heather Volpp, MD

PULS Testing

Beyond the Standard Lipid Panel

The PULS Cardiac Test measures a comprehensive panel of cardiovascular inflammatory biomarkers — many of which are not included in routine bloodwork. Blood is drawn at SynergyO3 and sent FedEx Overnight to Morning Star Labs. Results give both patient and physician a quantitative picture of arterial inflammation before and after protocol.

Circulation & Oxygenation

What EBOO Does to the Blood

EBOO increases the oxygen-carrying capacity of red blood cells, improves microcirculation, and reduces the viscosity of blood — all of which directly support cardiovascular function. For patients with poor circulation, post-cardiac events, or persistent inflammatory burden, this systemic effect is central to the therapeutic value.

Blood Thinners & Anticoagulants

Full Disclosure Required

Patients on anticoagulants (Eliquis, Warfarin, Xarelto) or with active blood clotting disorders must disclose this during the physician consultation. These are not automatic contraindications for EBOO, but they significantly affect protocol design. Dr. Volpp will evaluate your specific situation before any treatment begins.

Recovery Optimization

Pre & Post-Surgical
Recovery

Surgery is a significant physiological stress — creating acute inflammation, immune burden, and oxidative load that the body must work through during recovery. EBOO ozone therapy, used in the period before and after surgery, can support the body's natural healing processes by optimizing oxygenation, reducing systemic inflammation, and priming immune function for the demands of surgical recovery.

"The body's ability to heal after surgery depends entirely on the condition it's in going into it. Pre-surgical EBOO is about giving your biology every advantage before the stress begins." — Dr. Heather Volpp, MD

Pre-Surgical EBOO

Optimizing Before the Procedure

1–3 EBOO sessions in the weeks before a planned surgery can help optimize blood oxygen delivery, reduce baseline inflammatory burden, and support immune readiness. Patients who arrive at surgery in a better physiological state consistently report more comfortable recoveries and reduced post-operative complications.

Post-Surgical EBOO

Accelerating the Recovery Window

After surgery, EBOO supports recovery by reducing the acute inflammatory cascade, improving oxygenation to healing tissues, and helping restore immune function taxed by anesthesia and the surgical process. Timing relative to your procedure must be reviewed by Dr. Volpp — generally beginning 2–4 weeks post-op depending on the procedure.

Coordination with Surgeon

We Work Alongside Your Surgical Team

For planned procedures, we recommend informing your surgeon that you are pursuing adjunctive ozone therapy. Dr. Volpp can review your surgical plan during consultation and design a protocol that complements — not conflicts with — your surgical timeline and any post-operative restrictions from your care team.

Optimization & Prevention

Longevity &
Optimization

Not every EBOO patient is sick. A growing segment of our patients are healthy, proactive individuals who understand that cellular aging, oxidative accumulation, and subclinical inflammation begin long before symptoms appear. EBOO ozone therapy as a longevity tool is about maintaining biological resilience — giving your system the conditions it needs to function at the highest level for the longest time.

"Longevity medicine isn't about living longer. It's about ensuring that the years you have are years of actual function — energy, clarity, strength, and resilience. EBOO is one of the most powerful tools I know for maintaining that." — Dr. Heather Volpp, MD

Mitochondrial Health

The Engine of Biological Aging

Mitochondrial decline is one of the primary drivers of biological aging — decreased ATP production, increased reactive oxygen species, and reduced cellular repair capacity. Ozone therapy has been shown to stimulate mitochondrial activity and upregulate the body's own antioxidant enzyme systems, supporting the cellular energy infrastructure that underpins every aspect of vitality.

Proactive Use

EBOO as a Periodic Reset

Many longevity-focused patients use EBOO on a quarterly or semi-annual basis — not because they are symptomatic, but because they understand that subclinical oxidative accumulation and inflammatory burden don't announce themselves until they become problems. EBOO is the systemic reset that keeps the baseline clean.

Pairing Well

HOCATT® for Ongoing Maintenance

For longevity patients, HOCATT® is an ideal between-EBOO tool — the 10-session package at $1,440 provides ongoing transdermal ozone, PEMF, and infrared support on a flexible schedule. Many healthy patients maintain monthly HOCATT® sessions and annual EBOO sessions as their baseline wellness protocol.

Systemic Condition

Chronic
Inflammation

Chronic low-grade inflammation is the common thread underlying virtually every major chronic disease — cardiovascular disease, metabolic dysfunction, neurodegeneration, autoimmune conditions, and cancer. It is often present for years before it produces identifiable symptoms, and it is rarely addressed systemically by conventional medicine. EBOO ozone therapy works at the source — modulating the inflammatory cascade in the blood.

"Inflammation isn't the enemy — it's the immune system's tool. The problem is when that tool gets stuck in the 'on' position. EBOO helps turn the signal down without disabling the system." — Dr. Heather Volpp, MD

Root Causes We Investigate

What's Driving the Inflammation?

Chronic inflammation is a downstream effect, not a root cause in itself. The physician intake at SynergyO3 investigates the drivers — toxic burden, pathogen load, gut dysbiosis, metabolic dysfunction, poor sleep, dietary patterns — and designs the EBOO protocol to address the upstream sources, not just the inflammatory signal they produce.

Measurable Progress

Tracking Inflammation Before & After

The PULS Cardiovascular Test provides a quantitative baseline of inflammatory markers before your protocol begins. Repeating the panel after 3–5 EBOO sessions gives both you and Dr. Volpp an objective measure of your body's response — making the protocol adjustable and the progress visible, not just felt.

The HOCATT® Complement

Anti-Inflammatory Modalities Combined

HOCATT® delivers far infrared heat, transdermal ozone, CO₂, and PEMF simultaneously — each with documented anti-inflammatory mechanisms. For patients with systemic chronic inflammation, pairing HOCATT® sessions with EBOO creates a multi-pathway approach that addresses inflammation through blood, lymphatic, and tissue simultaneously.

Neurological & Pain

Neuropathy &
Chronic Pain

Peripheral neuropathy, chronic back pain, disc herniation, and degenerative joint conditions share a common feature: persistent local and systemic inflammation that degrades tissue, impairs nerve function, and resists the management strategies that address acute pain. EBOO's systemic anti-inflammatory and oxygenating effects — delivered directly through the blood — address the inflammatory environment that keeps these conditions chronic.

"Neuropathy patients often come to us after exhausting injection, surgical, and medication options. EBOO works systemically — not just at the site of pain — which is why it sometimes reaches what more targeted interventions haven't." — Dr. Heather Volpp, MD

PEMF Therapy

Targeted Nerve & Tissue Support

Pulsed Electromagnetic Field therapy — included with every HOCATT® session — has documented effects on nerve regeneration, pain modulation, and tissue healing. For neuropathy patients, PEMF provides a complementary mechanism to EBOO's systemic anti-inflammatory effect, targeting peripheral nerve function directly through electromagnetic stimulation.

Systemic vs. Local

Why Systemic Treatment Reaches Chronic Pain

Most pain interventions — injections, physical therapy, nerve blocks — address a local site. Chronic pain often has a systemic inflammatory driver that local treatment cannot reach. EBOO's blood-level anti-inflammatory effect reduces the systemic inflammatory environment that feeds chronic pain conditions, sometimes producing changes that location-specific treatments have not.

Referral Integration

Working With Your Pain Specialist

Many neuropathy and chronic pain patients come to us referred by chiropractors, pain management physicians, and neurologists who have reached the limits of their own toolkit. Dr. Volpp welcomes coordination with your existing care team and can discuss the EBOO protocol directly with your specialist if helpful.