Long COVID is a measurable biological disease — not anxiety, not deconditioning. SynergyO3 addresses its root mechanisms: mitochondrial dysfunction, micro-vascular injury, and persistent immune dysregulation, building a physician-supervised protocol to restore function and quality of life.
Long COVID affects multiple organ systems simultaneously. Symptoms may fluctuate, worsen with exertion (post-exertional malaise), and persist 12+ weeks after acute infection. Individual results vary — Dr. Volpp evaluates each patient’s complete clinical picture.
Symptoms typically emerge 4–12 weeks after acute SARS-CoV-2 infection and may persist for months to years. Approximately 1 in 10 COVID patients develop Long COVID regardless of initial illness severity.
Research suggests Long COVID patients may show elevated D-dimer and fibrinogen (microclotting), reduced VO₂ max (mitochondrial impairment), dysregulated cytokine profiles, and reactivated latent viral markers.
Long COVID is defined by symptoms persisting beyond 12 weeks after acute SARS-CoV-2 infection. Research suggests it is not a single entity but a constellation of post-viral syndromes driven by distinct but overlapping biological mechanisms that may vary by patient.
SARS-CoV-2 may disrupt mitochondrial membrane integrity and impair oxidative phosphorylation — the process by which cells generate ATP energy. This helps explain the characteristic energy depletion and post-exertional malaise that are hallmarks of Long COVID.
Emerging research indicates persistent micro-thrombi (tiny clots) may reduce oxygen delivery to tissues including the brain, muscles, and peripheral nerves. Elevated D-dimer and fibrinogen levels are associated findings in some Long COVID patients.
Some patients show evidence of persistent viral antigen reservoirs, reactivation of latent herpesviruses (EBV, HHV-6), and dysregulated cytokine signaling. These immune abnormalities are associated with ongoing inflammation and symptom perpetuation. SynergyO3’s approach targets these upstream biological drivers rather than managing individual symptoms in isolation.
Dr. Volpp evaluates each patient’s complete picture — identifying which biological mechanisms are most active — before any protocol is designed. Individual results vary.
Impaired cellular energy production (ATP) drives fatigue, PEM, and exercise intolerance. SARS-CoV-2 may damage mitochondrial membranes and disrupt oxidative phosphorylation at the cellular level.
Persistent micro-thrombi and endothelial injury may reduce tissue oxygen delivery. Associated with elevated inflammatory markers, brain fog, chest symptoms, and small fiber neuropathy presentations.
Ongoing immune activation, reactivated latent viruses (EBV, HHV-6), and dysregulated cytokine signaling may perpetuate symptoms months after the initial infection has resolved.
All protocols are physician-designed and supervised by Dr. Heather Volpp, MD. Therapies are selected based on each patient’s evaluation. Results may vary — these therapies are not FDA-approved to treat Long COVID.
Extracorporeal Blood Oxygenation and Ozonation (EBOO) filters blood and introduces medical-grade ozone, which may trigger antioxidant enzyme upregulation, reduce inflammatory burden, and support microvascular circulation.
The HOCATT combines ozone steam, carbonic acid, far-infrared, and full-spectrum light in a single 30-minute session. May support lymphatic flow, mitochondrial activation, and autonomic nervous system regulation.
Every patient begins with a comprehensive physician evaluation. No protocol begins before Dr. Volpp has reviewed your complete clinical picture.
A comprehensive intake with Dr. Volpp reviewing your symptom timeline, prior lab work, medications, and functional status. Targeted lab panels are ordered to identify active biological drivers.
Weeks 1–2Based on your evaluation findings, Dr. Volpp designs a sequenced treatment protocol — typically combining EBOO sessions, HOCATT therapy, and IV nutrient support at clinically appropriate intervals.
Weeks 3–10Functional benchmarks and symptom tracking guide protocol adjustments. Follow-up labs assess inflammatory markers and key biomarkers. Treatment frequency is adjusted as you progress toward your goals.
OngoingBegin with a comprehensive consultation with Dr. Heather Volpp, MD — Board-Certified Internal Medicine. Your evaluation will review your full clinical picture and identify which biological mechanisms may be driving your symptoms.
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