Every patient begins with a consultation with Dr. Heather Volpp, MD. Your full clinical picture is reviewed before any protocol is designed.
SynergyO3 identifies upstream biological drivers — oxidative stress, toxin burden, immune dysregulation, pathogen load — rather than treating symptoms in isolation.
EBOO, HOCATT®, IV therapy, and regenerative biologics work as a system — addressing multiple physiological drivers simultaneously for compounding outcomes.
Mold toxicity — formally known as Chronic Inflammatory Response Syndrome (CIRS) when triggered by water-damaged buildings — is not an allergy. It is a complex multisystem illness driven by mycotoxins: secondary metabolites produced by mold species including Stachybotrys, Aspergillus, and Penicillium.
Approximately 25% of the population carries the HLA-DR gene variant that impairs the body's ability to recognize and excrete biotoxins. For these individuals, mycotoxin exposure results in accumulation rather than elimination — triggering a dysregulated inflammatory cascade that affects the brain, immune system, hormones, and virtually every organ system.
Dr. Volpp evaluates CIRS using Shoemaker Protocol-informed testing: VCS testing, HLA-DR genotyping, TGF-beta1, C4a, MSH, MMP-9, VEGF, and leptin — building a complete picture of biotoxin burden and systemic inflammation before designing a detoxification protocol.
The HLA-DR gene variant is present in approximately 1 in 4 people and determines biotoxin clearance capacity. For these individuals, mold exposure creates accumulating illness that does not resolve with removal from the source alone.
Book Consultation →CIRS symptoms — brain fog, fatigue, mood disruption, sensory sensitivity — are frequently dismissed as anxiety, depression, or somatization. Patients spend years on psychiatric medications while the underlying biotoxin burden goes unaddressed.
Standard allergy tests for mold measure IgE responses to mold spores — not mycotoxin accumulation. A negative mold allergy test does not rule out CIRS or mycotoxin illness.
Removing yourself from a moldy environment stops ongoing exposure but does not clear mycotoxins already accumulated in tissue. Active detoxification and immune recalibration are required for clinical recovery.
Extra-corporeal Blood Ozone and Oxygenation (EBOO) is a closed-circuit medical procedure that ozonates your blood outside the body — driving systemic physiological changes targeted at the specific mechanisms driving your condition.
Ozone's oxidative chemistry directly neutralizes mycotoxins circulating in the blood — converting them to less harmful compounds that can be excreted through hepatic and renal pathways.
CIRS involves profound immune dysregulation. EBOO modulates overactivated complement pathways, reducing TGF-beta1 and C4a elevations that drive the chronic inflammatory cascade.
Mycotoxins are potently neurotoxic. EBOO's antioxidant upregulation (superoxide dismutase, catalase, glutathione) provides neuroprotection and supports cognitive recovery.
EBOO supports hepatic Phase I and II detoxification enzyme activity, accelerating mycotoxin processing through the liver and reducing total biotoxin burden.
HOCATT® is uniquely suited to CIRS and mold toxicity. Its combination of transdermal ozone, far-infrared heat, and carbonic acid stimulates whole-body detoxification through perspiration, lymphatic activation, and transdermal ozone absorption. The thermal component is especially valuable for patients with mycotoxin-driven musculoskeletal pain and temperature dysregulation — providing immediate symptomatic relief alongside the deeper detoxification benefit.
Ask About HOCATT® →Ozone absorbed through skin delivers anti-inflammatory effects without the intensity of systemic EBOO.
Deep tissue heating supports detoxification, reduces musculoskeletal pain, and stimulates mitochondrial activity.
CO2 dissolved in steam causes potent vasodilation — improving peripheral circulation and oxygen delivery.
Completely non-invasive. Patients sit reclined inside the HOCATT® pod. No needles, no downtime.
Mold allergy (IgE-mediated) causes typical allergic symptoms. Mold toxicity/CIRS is a multisystem biotoxin illness with fatigue, cognitive impairment, chemical sensitivities, and abnormal biomarkers. They are different conditions requiring different testing and treatment.
If your home has active water damage or mold growth, continued exposure makes recovery very difficult. Source identification and remediation are part of the protocol.
Visual Contrast Sensitivity (VCS) is a validated screening tool for biotoxin illness — CIRS patients typically show impaired ability to distinguish contrast at certain spatial frequencies.
EBOO directly oxidizes circulating mycotoxins and supports hepatic detoxification pathways. It is used alongside binders that capture mycotoxins in the gut for excretion.
Melanocyte-stimulating hormone (MSH) is a master regulator frequently depleted in CIRS — driving immune dysregulation, sleep disruption, pain amplification, and susceptibility to additional infections.
Most patients follow a 3-6 month active treatment protocol. Recovery timelines vary significantly based on duration of exposure, genetic susceptibility, and total biotoxin burden.
Yes — and this is more common than recognized. Both create overlapping CIRS-like presentations and each makes the other harder to treat.
Insurance is not accepted. Superbills for HSA/FSA are available. Written pricing is provided before all services.
Before any treatment begins, Dr. Volpp reviews your complete health history, labs, and goals. Every protocol is physician-designed for your specific biology — not a template.
Book Your Consultation →(760) 450-4602 · info@synergyo3.com · Mon-Fri 9:00am-5:00pm
Insurance not accepted · HSA/FSA superbills available · Written quotes before all services