CONDITIONS WE TREAT
Autoimmune conditions arise when the immune system attacks the body's own tissues. SynergyO3 investigates the upstream biological drivers — oxidative stress, gut permeability, chronic infection, and immune imbalance — to design a physician-supervised protocol targeting root mechanisms rather than symptom suppression alone.
CLINICAL PRESENTATION
Autoimmune conditions present with highly variable symptom patterns depending on which tissues are targeted. Many patients carry multiple diagnoses before receiving appropriate care. Individual results vary — Dr. Volpp evaluates each patient's complete picture.
SynergyO3 works with patients managing Lupus (SLE), Rheumatoid Arthritis, Hashimoto's Thyroiditis, Multiple Sclerosis, Sjögren's Syndrome, Inflammatory Bowel Disease, Psoriasis, and other immune-mediated conditions. We complement (not replace) rheumatologic care.
Lab findings may include elevated ANA, anti-dsDNA, RF, anti-CCP, or disease-specific antibodies; elevated CRP and ESR; abnormal complement levels (C3/C4); elevated inflammatory cytokines (TNF-α, IL-6, IL-17); and signs of oxidative stress.
COMMONLY OVERLAPPING CONDITIONS
CLINICAL EDUCATION
Autoimmune disease involves a complex interplay of genetic susceptibility, environmental triggers, gut permeability, and immune dysregulation. The immune system's loss of self-tolerance leads to chronic inflammation that damages specific tissues. Upstream drivers — including oxidative stress, mitochondrial dysfunction, and chronic low-grade infection — perpetuate the cycle.
Pathogens, environmental toxins, or food antigens that structurally resemble self-proteins may trigger an immune response that cross-reacts with the body's own tissues. Once initiated, this self-perpetuating cycle can continue long after the original trigger resolves.
Intestinal barrier dysfunction ('leaky gut') allows bacterial endotoxins and undigested proteins to enter systemic circulation, continuously activating innate immune responses. Microbiome imbalance further shifts immune regulation toward pro-inflammatory Th17 pathways.
Chronic inflammation generates excessive reactive oxygen species that overwhelm antioxidant defenses, causing mitochondrial DNA damage, impaired energy production, and further immune activation — creating a self-sustaining inflammatory cycle.
KEY STATISTICS
Comprehensive intake, targeted labs, and biomarker assessment to map biological drivers.
Physician-designed sequenced protocol combining EBOO, HOCATT, and IV nutrients.
Follow-up labs, functional benchmarks, and protocol refinement based on response.
ROOT CAUSE INVESTIGATION
Dr. Volpp evaluates each patient's complete picture — identifying which biological mechanisms are most active — before any protocol is designed. Individual results vary.
Loss of immune regulatory balance shifts the system toward pro-inflammatory Th17 dominance and insufficient T-regulatory (Treg) suppression, perpetuating autoantibody production and tissue inflammation.
Sustained inflammation generates peroxynitrite, superoxide, and other reactive species that modify self-proteins, creating neo-antigens that further drive autoimmune reactivity and mitochondrial impairment.
Environmental exposures, toxins, and chronic infection may alter gene expression patterns that regulate immune tolerance — activating previously silenced inflammatory genes and impairing regulatory T-cell function.
TREATMENT APPROACH
All protocols are physician-designed and supervised by Dr. Heather Volpp, MD. Therapies are selected based on each patient's evaluation. Results may vary.
EBOO ozone therapy may modulate immune function by activating regulatory T-cells, reducing pro-inflammatory cytokines, and supporting mitochondrial health — addressing the oxidative and immune imbalances central to autoimmune disease progression.
The HOCATT's combination of ozone steam, far-infrared, and carbonic acid therapy may support lymphatic drainage of inflammatory mediators, reduce joint and muscle inflammation, and support autonomic regulation.
YOUR PATH FORWARD
Every patient begins with a comprehensive physician evaluation. No protocol begins before Dr. Volpp has reviewed your complete clinical picture.
A comprehensive intake with Dr. Volpp reviewing your symptom timeline, prior lab work, medications, and functional status. Targeted lab panels are ordered to identify active biological drivers.
Based on your evaluation findings, Dr. Volpp designs a sequenced treatment protocol — typically combining EBOO sessions, HOCATT therapy, and IV nutrient support at clinically appropriate intervals.
Functional benchmarks and symptom tracking guide protocol adjustments. Follow-up labs assess inflammatory markers and key biomarkers. Treatment frequency is adjusted as you progress toward your goals.
COMMON QUESTIONS
TAKE THE NEXT STEP
Begin with a comprehensive consultation with Dr. Heather Volpp, MD — Board-Certified Internal Medicine. Your evaluation will review your full clinical picture and identify which biological mechanisms may be driving your symptoms.
Book Your Appointment →Physician-Supervised · SynergyO3 Medical · Encinitas, CA · (760) 450-4602
Individual results vary. Consult with Dr. Volpp during your evaluation.
