Autoimmune disease is the immune system attacking the wrong target — driven by triggers that conventional immunosuppression rarely addresses. SynergyO3 works to identify and resolve the upstream drivers of immune dysregulation: gut permeability, toxin burden, infection triggers, and oxidative stress.
Recognition is the first step. Dr. Volpp evaluates your complete clinical picture at your physician-led consultation.
Every patient begins with a consultation with Dr. Heather Volpp, MD. Your full clinical picture is reviewed before any protocol is designed.
SynergyO3 identifies upstream biological drivers — oxidative stress, toxin burden, immune dysregulation, pathogen load — rather than treating symptoms in isolation.
EBOO, HOCATT®, IV therapy, and regenerative biologics work as a system — addressing multiple physiological drivers simultaneously for compounding outcomes.
Autoimmune disease occurs when the immune system loses tolerance to self-tissue and mounts an attack against the body's own cells and organs. It manifests across more than 80 distinct conditions — from Hashimoto's thyroiditis and rheumatoid arthritis to lupus, multiple sclerosis, Crohn's disease, and psoriasis.
What drives immune misfiring is increasingly well understood. The autoimmune triad — genetic susceptibility, intestinal permeability (leaky gut), and environmental triggers — explains why autoimmunity emerges in genetically predisposed individuals exposed to the right combination of pathogens, toxins, stress, and dietary insults.
Conventional treatment focuses on suppressing the immune response with corticosteroids, biologics, and DMARDs. SynergyO3 works upstream — identifying and addressing the triggers maintaining immune dysregulation, while supporting tissue repair and reducing the inflammatory burden driving flares.
Whether it is Hashimoto's, RA, lupus, or MS — the upstream drivers are often shared: gut permeability, molecular mimicry from infections, heavy metal burden, mold exposure, and chronic stress. Treating only the downstream inflammation misses the opportunity to address the trigger.
Book Consultation →Biologics and corticosteroids reduce immune activity but do not address why the immune system is dysregulated. Long-term immunosuppression increases infection risk and masks rather than resolves the underlying process.
Intestinal permeability is a central mechanism in autoimmunity. When the gut barrier is compromised, food antigens and microbial products enter the bloodstream and drive immune activation. Standard autoimmune care rarely assesses or addresses gut status.
Molecular mimicry — where pathogen proteins resemble self-tissue proteins — is a documented autoimmune trigger. Unresolved infections maintaining immune activation are rarely investigated in standard care.
Extra-corporeal Blood Ozone and Oxygenation (EBOO) is a closed-circuit medical procedure that ozonates your blood outside the body — driving systemic physiological changes targeted at the specific mechanisms driving your condition.
Unlike immunosuppressants, EBOO modulates the immune response — calming overactivation while supporting appropriate immune function. This distinction is critical for patients with chronic infection triggers.
Autoimmune flares are driven and sustained by oxidative stress. EBOO activates the Nrf2 pathway, upregulating superoxide dismutase and glutathione — reducing the oxidative burden that amplifies immune reactivity.
Ozone therapy has documented effects on pro-inflammatory cytokines including TNF-alpha, IL-1, and IL-6 — the same targets of many biologic medications, achieved through a different mechanism.
When autoimmunity is driven or maintained by a chronic infection trigger, EBOO's direct antimicrobial activity addresses the pathogen component fueling immune misfiring.
HOCATT® provides gentle, non-invasive systemic support for autoimmune patients — particularly valuable for those with joint pain, skin involvement, and fatigue. The far-infrared component reduces musculoskeletal inflammation. Carbonic acid improves tissue oxygenation. Transdermal ozone provides anti-inflammatory and antimicrobial effects without the intensity of EBOO — making it appropriate even during active flares.
Ask About HOCATT® →Ozone absorbed through skin delivers anti-inflammatory effects without the intensity of systemic EBOO.
Deep tissue heating supports detoxification, reduces musculoskeletal pain, and stimulates mitochondrial activity.
CO2 dissolved in steam causes potent vasodilation — improving peripheral circulation and oxygen delivery.
Completely non-invasive. Patients sit reclined inside the HOCATT® pod. No needles, no downtime.
Yes. Hashimoto's is driven by immune dysregulation and often maintained by gut permeability, infection triggers, and oxidative stress — all addressable with EBOO and the SynergyO3 protocol.
Not in most cases. SynergyO3 protocols are designed to work alongside conventional care. Dr. Volpp reviews all current medications at consultation.
Immunosuppressants reduce overall immune activity — increasing infection risk. EBOO modulates immune activity — calming dysregulation while supporting appropriate immune response and pathogen clearance.
Yes. Lupus involves significant vascular inflammation, oxidative stress, and immune dysregulation that respond to the EBOO + IV therapy + HOCATT® protocol.
Intestinal permeability allows bacterial antigens and undigested food proteins into the bloodstream, driving immune activation. Restoring gut barrier function is one of the most impactful interventions in autoimmune disease.
Many patients notice reduced fatigue and pain within 3-4 EBOO sessions. Lab marker improvement typically appears at the 6-8 week mark.
This depends on the specific condition and flare severity. HOCATT® is typically well-tolerated even during flares. Dr. Volpp assesses the most appropriate approach at consultation.
Insurance is not accepted. Superbills for HSA/FSA are available. Written pricing is provided before all services.
Before any treatment begins, Dr. Volpp reviews your complete health history, labs, and goals. Every protocol is physician-designed for your specific biology — not a template.
Book Your Consultation →(760) 450-4602 · info@synergyo3.com · Mon-Fri 9:00am-5:00pm
Insurance not accepted · HSA/FSA superbills available · Written quotes before all services