SynergyO3 Reset · Rejuvenate · Restore

Physician-Led Evaluation

Every patient begins with a consultation with Dr. Heather Volpp, MD. Your full clinical picture is reviewed before any protocol is designed.

Root Cause, Not Symptoms

SynergyO3 identifies upstream biological drivers — oxidative stress, toxin burden, immune dysregulation, pathogen load — rather than treating symptoms in isolation.

Integrated Protocols

EBOO, HOCATT®, IV therapy, and regenerative biologics work as a system — addressing multiple physiological drivers simultaneously for compounding outcomes.

Clinical Education

What Is Chronic Systemic Inflammation?

Inflammation is a normal immune response — essential for healing. But when it becomes chronic, low-grade, and unrelenting, it becomes the common thread behind conditions ranging from cardiovascular disease and diabetes to autoimmunity, neurodegenerative disease, and cancer.

Chronic systemic inflammation does not always announce itself with heat or redness. More often it appears as fatigue that sleep does not fix, cognitive cloudiness, unexplained weight gain, recurring pain, or immune dysregulation. Standard labs often look normal even when inflammatory burden is significant.

Dr. Volpp evaluates inflammatory markers including CRP, ESR, ferritin, homocysteine, and oxidative stress indicators to build a complete picture of your inflammatory load — then designs a protocol to address its drivers.

Root Cause Approach

Fire Down, Function Up

Rather than suppressing inflammation with medication alone, SynergyO3 identifies and addresses its upstream drivers: oxidative stress, microbial burden, toxic load, and immune dysregulation.

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Why Standard Medicine Falls Short

The Gaps Conventional Care Leaves Open

NSAIDs & Steroids

Anti-inflammatory medications mask symptoms while doing nothing to address the underlying drivers. Long-term use creates its own physiological burden.

Diet Advice Alone

Anti-inflammatory diets are supportive but insufficient when inflammatory load is driven by pathogens, toxins, or chronic infection — which diet cannot resolve.

Lab Work That Misses It

Standard CBC and metabolic panels frequently miss chronic low-grade inflammation. Without the right markers, the fire burns undetected for years.

EBOO Ozone Therapy

How Ozone Addresses Chronic Systemic Inflammation

Extra-corporeal Blood Ozone and Oxygenation (EBOO) is a closed-circuit medical procedure that ozonates your blood outside the body — driving systemic physiological changes targeted at the specific mechanisms driving your condition.

Ozone Oxidizes Inflammatory Triggers

Ozone directly neutralizes bacterial, viral, and mycotoxin-derived compounds that drive persistent immune activation and inflammatory signaling.

Upregulates Antioxidant Enzymes

EBOO activates Nrf2 pathways, increasing superoxide dismutase, catalase, and glutathione — the body's master anti-inflammatory defense systems.

Improves Mitochondrial Function

Chronic inflammation impairs cellular energy production. EBOO enhances oxygen utilization and ATP synthesis, restoring cellular energy at the source.

Modulates Immune Overactivation

Ozone therapy has documented immunomodulatory effects — calming overactive Th1/Th2 responses that drive systemic inflammatory burden.

How EBOO Works
01
Blood Draw
A small volume of your blood is drawn via IV access in a closed, sterile medical circuit.
02
Ozonation
Blood passes through a medical-grade ozone generator — ozone dissolves and reacts with blood components.
03
UV Illumination
Ozonated blood passes under UV light, activating photochemical therapeutic effects.
04
Return
Treated blood is returned to your body — the entire process takes approximately 45–60 minutes.
HOCATT® Ozone Sauna

The Complementary Protocol for Chronic Systemic Inflammation

HOCATT® delivers transdermal ozone, far-infrared heat, and carbonic acid therapy in a single 30-minute session. Heat-induced vasodilation enhances ozone tissue penetration. Far-infrared reduces musculoskeletal inflammation. Carbonic acid improves oxygen delivery to inflamed tissue — creating a compounding anti-inflammatory effect that complements EBOO at the systemic level.

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Transdermal Ozone

Ozone absorbed through skin delivers anti-inflammatory effects without the intensity of systemic EBOO.

Far-Infrared Heat

Deep tissue heating supports detoxification, reduces musculoskeletal pain, and stimulates mitochondrial activity.

Carbonic Acid

CO2 dissolved in steam causes potent vasodilation — improving peripheral circulation and oxygen delivery.

30-Minute Session

Completely non-invasive. Patients sit reclined inside the HOCATT® pod. No needles, no downtime.

Common Questions

Chronic Systemic Inflammation — Frequently Asked

How do I know if I have chronic systemic inflammation?

The most reliable way is through targeted lab testing. Elevated CRP, ESR, ferritin, homocysteine, and oxidative stress markers are key indicators. Many patients have been symptomatic for years with normal standard labs — targeted testing tells a different story.

Is ozone therapy safe for inflammation?

Yes. EBOO is performed by a physician, uses your own blood in a closed medical circuit, and has an excellent safety profile with extensive clinical literature.

How many EBOO sessions are needed?

Most patients begin with 4-6 sessions over 4-6 weeks. Anti-inflammatory response is measured via repeat labs at the end of the initial series.

Can HOCATT® replace EBOO?

They work through different mechanisms and are complementary. Both together produce the strongest clinical outcomes for systemic inflammation.

Do I need to stop my current medications?

No. SynergyO3 protocols are designed to work alongside conventional care. Dr. Volpp reviews all current medications at your consultation.

How long does it take to feel results?

Many patients notice reduced fatigue and cognitive improvement within the first 2-3 EBOO sessions. Measurable lab improvements typically appear at the 4-6 week mark.

Does insurance cover these treatments?

Insurance is not accepted. SynergyO3 provides superbills for potential HSA/FSA reimbursement. Written pricing is always provided before any service.

Is this appropriate for autoimmune conditions?

Yes — chronic inflammation is central to virtually all autoimmune presentations. See our Autoimmune page for condition-specific protocols.

◈ Physician-Led · Encinitas, CA

Your Consultation Is
the First Treatment.

Before any treatment begins, Dr. Volpp reviews your complete health history, labs, and goals. Every protocol is physician-designed for your specific biology — not a template.

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(760) 450-4602 · info@synergyo3.com · Mon-Fri 9:00am-5:00pm

Insurance not accepted · HSA/FSA superbills available · Written quotes before all services