Long COVID is a biological reality — not anxiety, not deconditioning. SynergyO3 addresses its root mechanisms: mitochondrial dysfunction, micro-vascular injury, immune dysregulation, and persistent viral burden — through EBOO ozone therapy, regenerative biologics, and physician-designed protocols built for post-viral recovery.
Recognition is the first step. Dr. Volpp evaluates your complete clinical picture at your physician-led consultation.
Every patient begins with a consultation with Dr. Heather Volpp, MD. Your full clinical picture is reviewed before any protocol is designed.
SynergyO3 identifies upstream biological drivers — oxidative stress, toxin burden, immune dysregulation, pathogen load — rather than treating symptoms in isolation.
EBOO, HOCATT®, IV therapy, and regenerative biologics work as a system — addressing multiple physiological drivers simultaneously for compounding outcomes.
Long COVID is defined by symptoms persisting beyond 12 weeks after acute SARS-CoV-2 infection — and it affects an estimated 10-30% of COVID survivors. It is not a single disease but a constellation of overlapping physiological disruptions driven by several distinct mechanisms.
Current research points to four primary drivers: persistent viral reservoir (spike protein fragments remaining in tissue), immune dysregulation (reactivation of latent viruses like EBV and persistent T-cell abnormalities), microvascular injury and microthrombi formation, and mitochondrial dysfunction causing cellular energy failure.
These mechanisms explain why Long COVID patients experience such a wide range of symptoms — and why treatments aimed at only one driver rarely produce complete resolution. SynergyO3's approach addresses all four simultaneously through EBOO, targeted IV therapy, and regenerative support.
Long COVID patients show measurable abnormalities: elevated D-dimer and fibrinogen, microclots visible on microscopy, reactivated EBV, abnormal cytokine profiles, and mitochondrial dysfunction. These are biological findings requiring biological interventions.
Book Consultation →The most common advice given to Long COVID patients — rest and wait — has not produced recovery for the majority. Post-exertional malaise means pushing through makes things worse. But passive waiting leaves the underlying drivers unaddressed.
Prescribing an inhaler for breathlessness, an antidepressant for mood, and a sleep medication for insomnia addresses the symptoms but not the shared biology driving all of them.
Microthrombi and fibrinogen-amyloid clots have been identified in Long COVID patients and may explain POTS, brain fog, and exercise intolerance. Standard care does not detect or address them.
Extra-corporeal Blood Ozone and Oxygenation (EBOO) is a closed-circuit medical procedure that ozonates your blood outside the body — driving systemic physiological changes targeted at the specific mechanisms driving your condition.
Ozone therapy improves red blood cell deformability and has documented fibrinolytic effects — directly addressing the microclotting and vascular pathology identified in Long COVID research.
Ozone's oxidative activity neutralizes viral particles and biotoxins, and enhances immune surveillance that may help clear persistent spike protein and latent viral reactivations.
Long COVID's most disabling symptom — post-exertional malaise — stems from mitochondrial dysfunction. EBOO directly enhances cellular oxygen utilization and ATP production.
EBOO modulates aberrant cytokine patterns and T-cell dysfunction that perpetuate Long COVID inflammation — supporting a return to coordinated, appropriate immune response.
HOCATT® is particularly valuable for Long COVID patients experiencing POTS and dysautonomia. The gradual thermal environment, combined with carbonic acid (a potent vasodilator) and transdermal ozone, improves vascular tone and circulation without demanding exercise-level exertion. The session is reclined, non-strenuous, and tolerable even for patients with significant post-exertional malaise.
Ask About HOCATT® →Ozone absorbed through skin delivers anti-inflammatory effects without the intensity of systemic EBOO.
Deep tissue heating supports detoxification, reduces musculoskeletal pain, and stimulates mitochondrial activity.
CO2 dissolved in steam causes potent vasodilation — improving peripheral circulation and oxygen delivery.
Completely non-invasive. Patients sit reclined inside the HOCATT® pod. No needles, no downtime.
Long COVID is defined by symptoms persisting 12+ weeks after infection, with post-exertional malaise — where activity worsens symptoms. It involves distinct biological abnormalities not present in normal recovery.
Yes. EBOO addresses the microvascular and autonomic dysfunction implicated in Long COVID POTS. HOCATT®'s carbonic acid and thermal vasodilation also specifically support vascular tone.
Emerging research supports ozone therapy's effects on the specific mechanisms implicated in Long COVID: microclot dissolution, mitochondrial support, viral clearance, and immune modulation.
Most Long COVID patients begin with 6-10 EBOO sessions over 6-8 weeks, paired with HOCATT® 1-2x/week. Response varies — some improve significantly in 3-4 sessions; others require a full 12-week protocol.
NAD+ IV therapy is often included in Long COVID protocols given NAD's central role in mitochondrial function and immune regulation — both severely disrupted in Long COVID.
Yes. The EBOO + mitochondrial support protocol directly addresses the cellular energy failure driving post-exertional malaise.
Dr. Volpp reviews your vaccination schedule and timing at consultation. In most cases, a reasonable interval between any immune-stimulating treatment and EBOO is recommended.
Insurance is not accepted. Superbills for HSA/FSA are available. Written pricing is always provided before any service.
Before any treatment begins, Dr. Volpp reviews your complete health history, labs, and goals. Every protocol is physician-designed for your specific biology — not a template.
Book Your Consultation →(760) 450-4602 · info@synergyo3.com · Mon-Fri 9:00am-5:00pm
Insurance not accepted · HSA/FSA superbills available · Written quotes before all services