Physician-Supervised Protocol · Encinitas, CA
Extracorporeal Blood Ozonation & Oxygenation
EBOO is a medical-grade ozone therapy that filters and ozonates your blood outside the body — activating your natural antioxidant response, reducing systemic inflammation, and supporting immune function. Every session is designed and supervised by Dr. Heather Volpp, MD.
$1,100 per session · 90-minute session · MD-supervised protocol
The EBOO Closed-Loop Process
Your blood travels a sealed, single-use circuit — drawn, pumped, filtered, then enriched with medical-grade ozone and oxygen before it returns. It never contacts open air, and Dr. Volpp supervises throughout.
What to Expect at Your EBOO Appointment
From your first consultation to your follow-up, here is what the SynergyO3 EBOO experience looks like.
Initial Consultation with Dr. Volpp
Your first appointment is a 1:1 consultation with Dr. Volpp — not a nurse or coordinator. She reviews your medical history, current symptoms, medications, and any relevant labs. If EBOO is appropriate, she designs your protocol. Consultation fee: $150, applied toward your first EBOO session.
Pre-Treatment Lab Review (If Required)
For some patients, Dr. Volpp may request recent labs before proceeding — particularly for those with complex conditions, current medications, or first-time EBOO candidates. This ensures contraindications are ruled out and the protocol is appropriately calibrated.
EBOO Session
You arrive at SynergyO3 and are seated in a comfortable treatment chair. A small-gauge IV catheter is placed, the EBOO circuit is connected, and the session begins. The process is quiet and calm — most patients read, rest, or listen to music. Vitals are monitored throughout.
Post-Session Follow-Up & Protocol Adjustment
Dr. Volpp follows up to assess your response and refine your protocol. Many patients begin with a series of sessions — the appropriate frequency depends on your condition, baseline health, and goals. Results vary by individual; Dr. Volpp reviews outcomes honestly at every step.
Is EBOO Right for You?
Dr. Volpp screens every patient individually. Honesty about candidacy is a core part of how we practice medicine.
EBOO May Be Appropriate For
Patients dealing with systemic, complex, or chronic conditions where conventional medicine has not fully resolved symptoms, and who are looking for adjunctive physician-supervised care.
- Chronic illness with inflammatory component
- Post-viral or Long COVID syndrome
- Mold/mycotoxin or environmental toxicity
- Autoimmune conditions (case-by-case)
- Cancer support alongside oncology care
- Athletic recovery and performance optimization
- Patients seeking root-cause systemic support
Contraindications — EBOO May Not Be Appropriate For
Dr. Volpp screens all patients for known contraindications to ozone therapy before any treatment takes place. Safety comes first.
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency
- Active bleeding disorders or anticoagulation therapy
- Hyperthyroidism (uncontrolled)
- Pregnancy
- Acute myocardial infarction (recent)
- Seizure disorders (case-by-case)
- Severe anemia
This list is not exhaustive. Dr. Volpp conducts a complete medical review for each patient.
EBOO Session Pricing
No hidden fees. No pressure. The $150 consultation fee is credited toward your first EBOO session if you proceed with treatment.
Single Session
per session
- ~60-minute session
- Physician-supervised protocol
- Vitals monitoring throughout
- Post-session check before discharge
EBOO + UV Light
per session
- All Single Session inclusions
- UV light therapy added to EBOO circuit
- Enhanced pathogen & immune support
3-Session Package
$1,050 per session — save $50 per session
- 3 EBOO sessions
- Physician-supervised each visit
- Save $150 total vs. single pricing
5-Session Package
$1,000 per session — save $100 per session
- 5 EBOO sessions
- Physician-supervised each visit
- Save $500 total vs. single pricing
- Most chosen protocol for lasting results
5-Session Package + UV
$1,150 per session — save $100 per session
- 5 EBOO + UV Light sessions
- Physician-supervised each visit
- Save $500 total vs. UV single pricing
Initial Consultation
credited toward your first EBOO session
- Meet with Dr. Volpp, MD
- Health history & goals review
- Personalized treatment plan
- Fee fully applied to first session
Pricing is subject to change. Most insurance plans do not cover EBOO therapy. SynergyO3 operates on a direct-pay model. HSA/FSA funds may be applicable in some cases.
The Clinic Experience
A clinical environment built for comfort, clarity, and physician-supervised care — not a spa, not a wellness center.
Every EBOO Session Is Supervised by a Board-Certified MD
Dr. Heather Volpp, MD earned her medical degree from the University of Nevada, Reno School of Medicine in 2001, completed her residency in internal medicine at Cedars-Sinai Medical Center (2001–2004), and trained in allergy and immunology at UCLA/VA Greater Los Angeles (2004–2006). She has been in clinical practice in North San Diego County since 2006.
This is not a clinic where a technician follows a template. Dr. Volpp personally reviews every patient's medical history, medications, and relevant lab work before any treatment plan is developed. She is your physician of record throughout your care at SynergyO3.
"I saw numerous patients with fairly large systemic complaints — ranging from joint pain, fatigue, loss of mental clarity — that could not be addressed or explained by traditional medicine. This started to show me that we weren't addressing underlying problems, mainly inflammation, as a root cause."
— Dr. Heather Volpp, MD · SynergyO3
Frequently Asked Questions
Is EBOO ozone therapy FDA-approved?
No. EBOO is not FDA-approved as a treatment for any specific condition. Medical ozone has a long history of clinical use in Europe and is studied in peer-reviewed literature, but it falls outside standard FDA approval pathways as a therapy. At SynergyO3, EBOO is offered as adjunctive support — meaning it works alongside, not in place of, evidence-based medical care. Dr. Volpp is transparent about this distinction with every patient.
Are there real contraindications? What happens if I have one?
Yes, and we take this seriously. G6PD deficiency is an absolute contraindication — ozone therapy in a G6PD-deficient patient can cause hemolytic anemia. Active bleeding disorders, uncontrolled hyperthyroidism, pregnancy, and recent cardiac events are also considerations. Dr. Volpp screens for these in your consultation. If you have a contraindication, she will tell you clearly and recommend appropriate alternatives.
What does EBOO feel like during and after the session?
During the session, most patients describe it as quiet and unremarkable — you sit in a reclining chair for approximately 60 minutes while the EBOO circuit runs. There is minimal discomfort beyond the IV placement. Afterward, some patients feel slightly fatigued, while others report feeling clearer within 24–48 hours. Individual responses vary considerably.
How many sessions will I need?
This depends entirely on your condition, baseline health, and goals — which is why we require a consultation before booking sessions. Some patients see meaningful improvement after three to five sessions; others benefit from ongoing periodic treatment. Dr. Volpp reassesses your protocol at each visit.
Can EBOO be combined with my conventional medical treatment?
In most cases, yes. SynergyO3 is explicitly designed to work alongside your existing medical care — not to replace it. Dr. Volpp will ask about all current medications and treatments during your consultation and will flag any potential interactions.
How is EBOO different from other ozone therapies?
EBOO processes a significantly larger blood volume per session than single-pass ozone IV therapy (MAH). The blood passes through a filter and a closed ozone circuit. HOCATT delivers ozone transdermally through steam — a different mechanism and a different use case. Dr. Volpp can help you determine which approach is appropriate for your specific situation.
Does SynergyO3 accept insurance for EBOO?
EBOO therapy is generally not covered by standard health insurance plans. SynergyO3 operates on a direct-pay model. In some cases, HSA and FSA funds may be applicable — we can provide a detailed superbill.
Begin with a Consultation
A 1:1 appointment with Dr. Volpp to review your health history, answer every question you have, and determine whether EBOO — or any other approach at SynergyO3 — is appropriate for you. No obligation. Complete transparency.
Consultation fee of $150 is credited toward your first EBOO session if you proceed. Individual results vary. EBOO is not FDA-approved to treat any disease.