EBOO (Extracorporeal Blood Ozonation & Oxygenation) filters and ozonates 1.8–3 liters of your blood outside the body — processing up to 15× more blood than traditional ozone methods. Physician-supervised at SynergyO3 in Encinitas, serving North County San Diego.
Also known as EBO2 (Extracorporeal Blood Ozonation & Oxygenation), EBOO removes inflammatory debris through physical filtration before ozone re-delivery — a capability no IV bag therapy can replicate.
Physician-led & MD-supervised · Dr. Volpp reviews health history, medications & protocol at every consultation
Standard major autohemotherapy treats 70–200ml. EBOO processes up to 3 liters — a fundamentally different physiological scale.
A proprietary filter captures lipids, proteins, and cellular waste as blood passes through — before ozone delivery begins.
Dr. Volpp reviews your complete health picture, contraindications, and therapeutic goals before your first and every subsequent session.
"EBOO is the most complete ozone platform I offer. It combines physical filtration of blood with high-dose ozone delivery — achieving systemic effects that topical or minor therapies simply cannot reach."
Two IV lines are placed — one to draw blood out, one to return it. The circuit runs continuously at a calibrated rate throughout the session.
Blood passes through a proprietary filter that captures lipids, cellular debris, and inflammatory proteins — a step unique to EBOO/EBO2.
Filtered blood is exposed to a precise ozone/oxygen mixture. Concentration is calibrated per session to your therapeutic goals.
Ozonated, filtered blood returns to your body through the second IV line — continuously, for the duration of the session (~60 min).
Ozone activates the NF-kB pathway and triggers a controlled oxidative burst that upregulates your body's own antioxidant enzymes — superoxide dismutase, catalase, and glutathione peroxidase — resetting redox balance.
Filtered, ozonated blood dramatically increases dissolved oxygen delivery to tissues. Mitochondrial function improves, energy production rises, and oxygen-starved cells begin to recover — measurably, within sessions.
Ozone modulates cytokine signaling, reducing pro-inflammatory IL-6 and TNF-α while supporting regulatory T-cell function. The result: a more measured, less reactive immune state across multiple body systems.
All ozone therapies are not equal. EBOO and EBO2 represent the same extracorporeal blood ozonation approach — filtering and ozonating blood outside the body at volumes 9–15× greater than traditional IV methods.
HOCATT® and EBOO are highly complementary — addressing ozone delivery through different pathways. Dr. Volpp can combine both into a single protocol for amplified outcomes.
| Category | EBOO / EBO2 | Major Autohemotherapy (MAH) | HOCATT® Ozone Sauna |
|---|---|---|---|
| Blood Volume Treated | 1.8–3 Liters | 70–200 mL | Transdermal / No IV |
| Physical Filtration | Yes — proprietary filter | No | No |
| Delivery Method | Extracorporeal circuit | IV bag + reinfusion | Whole-body transdermal |
| Session Duration | ~60 min | ~90–120 min | ~45 min |
| Ozone Dose Control | High precision | Moderate | Indirect |
| Systemic Reach | Full circulatory system | Partial | Skin + lungs + pores |
| Best For | Chronic illness, immune, longevity | Mild immune support | Energy, detox, relaxation |
| Contraindication Complexity | High — G6PD, bleeding, etc. | Moderate | Lower |
| Pairs Well With | HOCATT®, Exosomes, Aesthetics | HOCATT® | EBOO, Aesthetics |
EBOO + HOCATT® Protocol: Many patients achieve amplified results by combining EBOO's circulatory ozone delivery with HOCATT®'s transdermal and respiratory pathways. Dr. Volpp designs combination protocols at consultation based on your specific health history and goals.
EBOO is most impactful for patients with complex, systemic health challenges — particularly where inflammation, immune dysregulation, or mitochondrial dysfunction are driving symptoms. All candidates begin with a physician-led consultation and medical history review.
Post-viral mitochondrial dysfunction, fatigue that does not resolve with rest, brain fog, post-exertional malaise — EBOO addresses root-level oxidative and immune contributors.
Mold toxins suppress mitochondrial function and drive systemic inflammation. EBOO's filtration step physically removes circulating debris while ozone addresses the inflammatory cascade.
Ozone has direct antimicrobial properties against certain bacterial and viral pathogens. Combined with filtration, EBOO is used as part of multi-modal chronic Lyme protocols.
Immune dysregulation drives many autoimmune conditions. EBOO's cytokine modulation and T-regulatory cell support can reduce the intensity and frequency of flares over a protocol.
Improved blood viscosity, oxygen delivery, and circulation are among EBOO's most documented effects — beneficial for cardiovascular health and peripheral circulation.
Mitochondrial decline is central to aging. EBOO's hyperoxygenation and antioxidant enzyme upregulation provide a physiological reset used by proactive longevity-focused patients.
Used to optimize immune and cellular health before major procedures and support recovery afterward — reducing inflammatory burden during critical healing windows.
Whether from metabolic syndrome, chronic infection, or idiopathic origin — EBOO's multi-pathway anti-inflammatory action addresses systemic inflammation at a depth IV vitamins cannot.
† EBOO is offered as a wellness therapy. Individual results vary. These statements have not been evaluated by the FDA. EBOO is not intended to diagnose, treat, cure, or prevent any disease. Suitability is determined by physician evaluation at consultation.
Health check, vital signs, review of your protocol and any changes since last visit. IV access is confirmed prior to starting.
Two IV lines placed — one antecubital draw, one return. The circuit is primed and flow rate confirmed by the clinical team.
Blood draws through the circuit continuously. You are reclining comfortably. Mild warmth is common; significant discomfort is not expected.
IV lines flushed. Circuit closed. Vitals re-checked. You remain resting briefly before standing.
Most patients report increased energy and improved clarity beginning 24–48 hours post-session. Some feel fatigue immediately after — a normal immune activation response.
EBOO is not appropriate for all patients. Dr. Volpp screens for the following at consultation — this list is not exhaustive:
Continue hydrating. Avoid strenuous exercise for 12–24 hours. Some patients experience mild fatigue or light-headedness — this is a normal immune activation response and typically resolves within 24 hours. Subsequent sessions are spaced 1–2 weeks apart for most protocols.
EBOO does not work through a single mechanism. Its clinical value comes from the simultaneous activation of multiple physiological pathways — many of which amplify each other. This is why patients with complex, multi-system conditions often respond when single-target approaches have not.
Ozone-induced oxidative signaling activates mitochondrial biogenesis. Cells produce more ATP, increasing cellular energy at the source — particularly relevant in post-viral fatigue and chronic illness.
EBOO improves red blood cell deformability and reduces blood viscosity — enhancing oxygen delivery to peripheral tissues. Patients report improved circulation and warmth in extremities.
Ozone recalibrates the Th1/Th2 immune balance, reduces inflammatory cytokines (IL-6, TNF-α), and promotes regulatory T-cell activity — addressing immune overactivation without immunosuppression.
Rather than introducing external antioxidants, ozone stimulates your body's own enzymes — superoxide dismutase, catalase, glutathione peroxidase — creating a sustained endogenous antioxidant effect.
Ozone's direct oxidative capacity disrupts lipid envelopes of pathogens including bacteria, viruses, and fungi. This is one reason EBOO is used in chronic Lyme, mold illness, and EBV reactivation protocols.
Emerging research suggests high-volume ozone therapies may stimulate release of endogenous stem cells from bone marrow — supporting tissue repair and regeneration as part of a broader longevity protocol.
Clinical references available upon request. These statements reflect current peer-reviewed research and clinical experience. EBOO ozone therapy is offered as a wellness service. Individual results vary. Not FDA-approved for the treatment of any specific disease. All pathways described represent research-supported mechanisms, not guaranteed individual outcomes.
EBOO is a complex therapy with meaningful contraindications. Dr. Volpp's background in integrative medicine, IV therapy, and regenerative protocols ensures your protocol is both appropriate and optimized for your specific physiology — not a generic template.
"After 8 months of unexplained fatigue and cognitive fog following COVID, I finally started feeling like myself again after my third EBOO session. My energy came back first — then clarity. I can't recommend it enough to anyone going through post-viral illness."
Individual results vary · Physician evaluation required before treatment · Results referenced above reflect a single patient's reported experience
Best for new patients exploring EBOO for the first time. Includes physician consultation review and session monitoring.
Recommended starting protocol. $787.50/session — optimized for chronic conditions, immune support, and longevity goals.
Comprehensive protocol for complex chronic illness. $625/session — Dr. Volpp's recommended tier for sustained results.
UV light passes ozonated blood through an ultraviolet chamber before re-infusion, adding a secondary antimicrobial and immune-modulatory effect. Recommended for Lyme, mold illness, and chronic viral conditions.
Insurance not accepted · HSA/FSA superbills available upon request · Cancellations require 48-hour notice · Written quote provided before every service · Pricing subject to change — confirm at time of booking
They are the same therapy. EBOO (Extracorporeal Blood Ozonation & Oxygenation) and EBO2 are used interchangeably to describe the same extracorporeal blood ozone treatment. Some practitioners use EBO2 to emphasize the oxygenation component. At SynergyO3, we use EBOO as the standard terminology.
EBOO is offered as a wellness therapy and is not FDA-approved to treat any specific disease. Ozone therapy exists in a regulatory grey zone in the U.S. — it is practiced by licensed physicians in many states as part of integrative medicine. Dr. Volpp provides full transparency about the evidence base and regulatory status at consultation.
Yes. G6PD (glucose-6-phosphate dehydrogenase) deficiency is a contraindication for ozone therapy and must be ruled out before your first session. If you have not been previously tested, we can order this lab work prior to scheduling your first appointment.
Most conditions respond to a protocol of 4–8 sessions. Dr. Volpp recommends starting with a 4-session protocol and reassessing based on your clinical response. Some longevity and maintenance patients do single sessions quarterly after completing an initial protocol. There is no universal answer — it is always individualized.
Yes — and the outcomes are frequently amplified when combined. EBOO addresses systemic blood-level ozone and filtration; HOCATT® delivers transdermal, respiratory, and carbonic acid pathways. Together they provide comprehensive whole-body ozone coverage. Aesthetic treatments often perform better when systemic inflammation is reduced through EBOO. Timing and sequencing are determined at consultation.
Most patients feel mild warmth, a sense of relaxation, and occasionally mild pressure at the IV sites. The session is not painful. You will be reclining comfortably for approximately 60 minutes. Clinical staff are present throughout. Any discomfort is reported immediately and addressed.
Most patients report the first noticeable effects 24–48 hours after their second or third session. Common early responses include improved energy, mental clarity, and sleep quality. More significant shifts in chronic condition symptoms typically emerge over a full 4-session protocol. Dr. Volpp tracks your progress and adjusts accordingly.
Insurance is not accepted for EBOO or any IV therapy services. SynergyO3 provides a detailed superbill that can be submitted to HSA or FSA accounts for reimbursement. A written quote is always provided before any service is performed. We encourage you to verify your HSA/FSA coverage prior to your appointment.
Mild fatigue or light-headedness in the 12–24 hours after EBOO is a known immune activation response and typically self-resolving. Rest, hydrate, and avoid strenuous activity. If you experience more significant symptoms — chest tightness, significant dizziness, or symptoms that feel unusual — contact our office directly at (760) 450-4602. Dr. Volpp is available for follow-up consultations as needed.
EBOO delivers ozone at a scale and depth that no other approach can replicate. It begins with a physician consultation where Dr. Volpp reviews your health history, runs required labs, and builds the protocol your biology actually needs.
(760) 450-4602 · info@synergyo3.com · Mon–Fri 9:00am–5:00pm
Insurance not accepted · HSA/FSA superbills available · G6PD testing required before first session