EBOO · How EBOO Works

The Process

A sealed, single-use closed loop

EBOO moves your blood through a sterile, single-use circuit, drawn, filtered, ozonated and oxygenated, then returned. Here is each step, performed under Dr. Volpp’s supervision.

The Treatment

Blood, filtered and re-oxygenated — then returned to you.

EBOO — Extracorporeal Blood Ozonation & Oxygenation — passes your blood through a sterile filter while introducing medical-grade ozone and oxygen, then returns it to circulation. It’s our most-requested treatment, and every session is performed under the direct supervision of Dr. Heather Volpp, MD. Physician-led care — not a trend.

  • Filters

    A sterile, single-use circuit cleans the blood as it passes through.

  • Ozonates

    Medical-grade ozone drives oxidative signaling and immune modulation.

  • Oxygenates

    Oxygen is introduced to support delivery and uptake at the cellular level.

  • + Optional UV

    An ultraviolet light stage can be added for an additional effect.

The Hemealumen polychromatic UV device used for the optional UV light stage at SynergyO3
The optional UV stage, up closeSynergyO3’s polychromatic UV device — the equipment behind the “+Optional UV” stage above.

EBOO is offered alongside conventional medical care and is not a cure. Individual results vary. Consult with Dr. Volpp.

The Science Behind EBOO

Hormesis: How a Controlled Stress Strengthens the Body

Hormesis is a well-documented biological principle: a low, carefully dosed stressor prompts the body to adapt and become more resilient — while the same stressor at high, uncontrolled levels would be harmful. A measured workout is the everyday example: mild stress that signals your muscles, heart, and metabolism to strengthen.

EBOO works on the same principle. As your blood is gently filtered and reintroduced with medical-grade ozone, it delivers a precise, physician-supervised oxidative challenge — designed to activate your body’s own antioxidant and adaptive defenses.

The Dose Makes the Difference

The hormetic curve: benefit rises within a controlled dose range, then declines if the stressor becomes excessive. Protocols are dosed to stay in the beneficial zone.

baseline function beneficial zone Peak adaptive benefit Dose / intensity of stressor → Benefit →
Adaptive responseBaseline functionOptimal dose

Conceptual illustration for education — not patient data or a measured outcome.

What happens during EBOO

  1. 1

    A controlled oxidative stressor is introduced

    Your blood is filtered and reintroduced with medical-grade ozone — a mild, precisely dosed challenge, monitored throughout the session.

  2. 2

    Antioxidant defenses are signaled

    The body senses the mild oxidative stress and activates its natural antioxidant systems and cellular stress-response pathways.

  3. 3

    The system adapts and strengthens

    Research suggests these adaptive responses are associated with improved antioxidant capacity and a reduced oxidative and inflammatory burden over time.

Why this matters for EBOO

Because EBOO is grounded in hormesis, the goal is never “more is better” — it’s the right dose, delivered safely. Each protocol is designed or supervised by Dr. Volpp and dosed to stay within the beneficial range, so the body is challenged just enough to adapt. This is why EBOO is used alongside your existing care, and why every plan begins with an individual evaluation.

  • Precisely dosed
  • Physician-supervised
  • Adaptive, not forced
  • Individualized protocols

Physician-Supervised · Dr. Heather Volpp, MD — Board-Certified Internal Medicine (ABIM)

Schedule a Consultation

This information is educational and describes the biological mechanism of hormesis; it is not a promise of specific outcomes. Individual results vary. Ozone-based therapies are not FDA-approved to diagnose, treat, cure, or prevent any disease, and may not be appropriate for everyone. Consult with Dr. Volpp during a consultation to review benefits, contraindications, and whether a protocol is right for you.

Physician-Supervised

Ready to talk with Dr. Volpp?

EBOO is offered alongside your existing care. Dr. Heather Volpp, MD reviews every patient’s health profile before treatment; a $150 phone consultation is available on request and is credited toward your first EBOO treatment. Individual results vary.